A new series of 5-sulphonyl-(-nicotinonitriles, pyridones and cyclohexenones)-8-hydroxyquinolines 2, 3 and 4 have been synthesised by Michael condensation of 5-sulphonyl-(4'-arylidino-3-methyl-2-pyrazoline-5-one)-8-hydroxyquinoline 1 with malononitrile, ethylcyanoacetate and ethylacetoacetate respectively. The metaI chelates for compounds 2 and 3 with Cu2+ Hg2+ and Fe3+ have been synthesised. All the prepared compounds were screened in vitro with some selected Gram-positive and Gram-negative bacteria