The pre-crystallization kinetics of Pb10Se90 glass was determined under non-isothermal conditions using a differential scanning calorimetry (DSC) technique. Two isoconversional methods, the Kissinger-Akahire-Sunose and Vyazovkin methods, were used to determine the variation of the activation energy for glass transition with temperature. The results show that only one (three-dimensional growth) mechanism is working simultaneously during the amorphous-glass process of the investigated glass.