The pyrazolone derivative 4 was synthesized by reaction of carbohydrazide 2 with ethyl benzoylacetate
in ethanol and p-toluene sulphonic acid followed by cyclization upon heating in acetic acid.
Chloroacylation of amino ester and amino benzoyl compounds 1, 19 gave the chloro acetylamino derivatives
5 and 20 respectively which both of them react with different amines to afford compounds 6, 23a-d.
Hydrolysis and decarboxlation of compound 1 yielded the aminothienotetrahydroisoquinoline 8 which
was used as versatile material for synthesizing other heterocyclic compounds 9-18. Compound 20 react
with hexamethylenetetramine and malononitrile yielded thediazepino and pyrrolo derivatives 21, 22 respectively.
ملخص البحث
قسم البحث
مجلة البحث
Journal of the Chinese Chemical Society
المشارك في البحث
تصنيف البحث
1
عدد البحث
Vol. 58
سنة البحث
2011
صفحات البحث
PP. 544-554