Individuals with coexisting diabetes and metabolic syndrome have the highest prevalence of lipid
abnormalities and cardiovascular disease. The aim of this study give attention for the risk associated
with the increase of obesity rates and its complications in Egypt. This study was conducted on 91
subjects at Hospital of Sohag University to evaluate the relationship between levels of HbA1C, c-peptide
and lipid profile in obese and obese diabetic patients. The results showed that both obese and obese
diabetic subject has higher blood pressure, blood glucose, HbA1C, C-peptide, total cholesterol, TG, LDL-C and lower HDL than normal control subjects. In addition, the previous parameters were higher in diabetic obese than normal obese subject. It is concluded that these results suggest that HbA1c, C- peptide level can be used as tools for predicting the lipid profile of both normal obese and obese diabetic patients. Glycated hemoglobin (HbA1C) is the indicator of glycamic status over long term. C-peptide is inflammatory markers elevated in diabetic patients.