Abstract.Cathodic adsorptive stripping voltammetry
(CASV) was applied for the determination of rutin in
pharmaceuticals, human urine, and blood serum. An
electrochemical stripping procedure for trace measure-ments of rutin was developed based on the adsorption of
the Cu
2þ
-rutin complex on a hanging mercury drop
electrode and applied to the quantification of the drug.
Cyclic voltammetry was used to characterize the inter-facial and redox behavior of the adsorbed Cu
2þ
-rutin
complex. Experimental and instrumental parameters
for quantitative determination were optimized, and a
detection limit of 4.910
9
molL
1
in presence of
Cu
2þ-ions for quantification of rutin under optimum
conditions was derived. The sharp peak of the adsorbed
Cu
2þ
-rutin complex associated with an effective inter-facial accumulation of this compound facilitates the
determination of rutin in biological fluids with good
recoveries. The degree of interference from potentially
present metal ions and organic compounds on the
CASV signal for Cu
2þ
-rutin complex was evaluated.