Our ageing society is confronted with a dramatic increase in incidence of age-related neurodegenerative diseases; biomedical research leading to novel therapeutic strategies is crucial to address this problem. Animal models of neurodegenerative conditions are invaluable in improving our understanding of the molecular basis of pathology, potentially revealing novel targets for intervention. Here, we review transgenic animal models of Alzheimer’s and Parkinson’s disease reported in mice, zebrafish, Caenorhabditis elegans and Drosophila melanogaster. This information will enable researchers to compare different animal models targeting disease-associated molecules by genomic engineering and to facilitate the development of novel animal models for any particular study, depending on the ultimate research goals.
ملخص البحث
قسم البحث
مجلة البحث
Genes & genomics
المشارك في البحث
الناشر
Springer
تصنيف البحث
1
عدد البحث
35(4)
موقع البحث
http://link.springer.com/article/10.1007/s13258-013-0116-2
سنة البحث
2013
صفحات البحث
425–440