The liver is accountable for many critical functions within the body and loss of those functions can
cause significant damage to the body. Liver disease is a extensive term that covers all aspects that cause
the liver to fail to perform its proper functions. Acute liver failure indicates the development of severe
acute liver injury with impaired synthetic function without preexisting of clinical liver disease. However,
chronic liver disease is characterized by destruction of the hepatic tissue. Early changes, such as fatty
liver can progress via inflammation and fibrosis to cirrhosis. The main causes for liver dysfunction include
dyslipidemia, obesity, viral and parasitic infection, drugs and environmental pollution, alcohol abuse,
autoimmunity, and genetic defective such as hemochromatosis. The present review almost covers all the previous aspects that lead to liver dysfunction.