A series of single and mixed oxide nanocatalysts of mesoporous CuO-Fe2O3with different CuO contents(1–50 wt.%) were prepared by a co-precipitation method and further promoted by trace amounts ofCeO2, ZrO2and Ag2O (0.1–0.5 wt.%) dopants. The original and calcined catalysts were characterized byTG, DTA, XRD, TEM, VSM, N2sorption analysis, surface chemisorbed oxygen and DC electrical conductivitymeasurements. The catalytic performance of these nanocatalysts toward CO oxidation was studied using aconventional fixed bed flow type reactor. The results revealed that the addition of 1–20 wt.% CuO to Fe2O3monotonically increases the specific surface area, the amount of surface chemisorbed oxygen, electricalconductivity and catalytic activity of the nanocatalysts. In addition, the catalytic activity indicated thatFe-Cu mixed oxide nanocatalyst promoted with the three dopants (CeO2, ZrO2and Ag2O) exhibited thehighest catalytic activity with a total conversion of CO into CO2at 100◦C. Moreover, the activation energyof CO oxidation decreased from 38.4 to 23.1 kJmol−1upon treating the catalyst containing 20 wt.% CuOwith the three dopants. Finally the effects of various operational parameters were also studied.