Due to the biological importance of thienopyrimidine derivatives, we present here a synthetic way for the design of new thienopyrimidines (2‒11) using the precursor 2-(4-Oxo-9-phenyl-7-(p-tolylamino)-3,4-dihydropyrimido[4′,5′:4,5]thieno[2,3-d] pyrimidine-2-yl)acetohydrazide 1. Spectral analyses techniques (IR,1H NMR, and 13C NMR) were utilized to confirm the structures of all synthesized compounds. All the new compounds were screened for their anti-bacterial and anti-inflammatory activity showing significant results compared to the standard drug. A molecular docking approach was utilized to investigate the proposed molecular mechanism of the antibacterial and anti-inflammatory activity of the synthesized compounds. Drug-like properties were analyzed to highlight the potential oral drug candidates.
ملخص البحث
تاريخ البحث
قسم البحث
مجلة البحث
Journal of Molecular Structure
المشارك في البحث
الناشر
ELSEVIER
سنة البحث
2021