New 2-thioxopyrimidin-4-ones capable of participating in regioselective reactions with functionally diverse hydrazonoyl chlorides towards angular regioisomers, rather than linear ones, were designed and synthesized to form stereoisomeric cis- and trans-hexahydro [1,2,4]triazolo[4,3-a]quinazolin-9-ones to be tested as antitumor candidates. The angular regiochemistry of the products was verified through crystallographic experiments and NMR studies. In addition, the regioselectivity of the reaction was found to be independent of the stereochemistry of the used 2-thioxopyrimidin-4-one. Only compound 4c demonstrated satisfactory growth inhibition against all the cancer cells used among all the produced drugs.
ملخص البحث
تاريخ البحث
قسم البحث
مجلة البحث
Molecules
المشارك في البحث
الناشر
MDPI
عدد البحث
28(9)
موقع البحث
https://www.mdpi.com/1420-3049/28/9/3718
سنة البحث
2023
صفحات البحث
3718