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Anti-tumor effect of roxithromycin on hepatocarcinogenesis induced by N-nitrosodiethylamine and carbon tetrachloride in rats.

Research Authors
MS Youssef, MKA Rahman, AZ Mahmoud, YO El-Amir, J Köfer, H Schobesberger
Research Abstract

Abstract This paper evaluates the anti-tumor effect of Roxithromycin (RXM) on
hepatocarcinogenesis. Histopathologically, proliferative and neoplastic changes were the
main lesions induced in liver of rats by Nnitrosodiethylamine (NDEA) and carbon
tetrachloride (CCL 4). Computerized morphometrical analysis revealed that treatment with
RXM reduced the number and size of the eosinophilic preneoplastic foci as well as inhibited
the development of large cell dysplasia, hepatoma and hepatocellular carcinoma in nearly

Research Department
Research Journal
Animal hygiene and sustainable livestock production. Proceedings of the XVth International Congress of the International Society for Animal Hygiene, Vienna, Austria, 3-7 July
Research Member
Research Rank
3
Research Vol
Volume 3.
Research Year
2011
Research Pages
1435-1438