This study aimed to detection of the efficacy of some drugs used in the field for treatment of liver fluke infection in the cattle (Bos taurus) in Egypt. Treatment trials used for three groups of naturally infected animals (positive by coprological examination) with some anthelmintic drugs differ in their chemical groups (Ivomec super, Rafoxanide, and Triclabendazole) divided into three groups 10 animals in each one. The dose was repeated twice with 3 weeks in between. Animals were examined clinically and laboratory; also fecal samples were collected and examined microscopically each time for follow-up. Egg counting using (Modified Stoll's dilution technique) was done 3 times in each group (day 1, after 3 weeks post-treatment, 6 weeks post-treatment). The efficacy of the drug is measured by improved clinical state or reduction/ disappearance of Fasciola egg count. In group I (treated by Ivomec super): Egg per gram (EPG) before treatment was 800 egg/ gram and after treatment was 1280 egg/gram, Egg reduction rate (ERR) of Ivomec super was %-60. In group II (treated by Triclabendazole): EPG before treatment was 500 egg/ gram and after treatment was 80 egg/ gram, ERR of Triclabendazole was 84%. In group III (treated by Rafoxanide): EPG before treatment was 480 egg/ gram and after treatment was 160 egg/ gram, ERR of Rafoxanide was 66.6%. The anthelmintic drug wasn’t effective in the treatment of Fascioliasis as no progress in the clinical status of the infected animals and the ERR was less than 90%. Our study concluded that the ERR (egg reduction rate) of used anthelmintic drugs (Ivomec super, Triclabendazole, Rafoxanide) was less than the lower limit of the effective fasciolicides drug and the drugs wasn’t effective in treatment of fascioliasis