Potato Tuber Moth, Phthorimaea operculella (Zeller), is one of the most dangerous pests infesting the potato crop in Egypt. Herein, five selected pesticides (Indoxacarb, sulfoxaflor, emamectin benzoate, thiamethoxam + chlorantraniliprole, and Bacillus thuringiensis) were evaluated on 1st instar larvae of P. operculella under laboratory conditions. As results, indoxacarb was the most potent pesticide through selected pesticides with LC50 value of 55.08 μg/ml after 24-h of exposure. After 72-h of treatment, emamectin benzoate was the most toxic pesticide among selected pesticides with LC50 value of 22.96 μg/ml. Further investigations are required to set these selected pesticides within integrated pest management (IPM) programs to control P. operculella in Egypt.