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Synthesis of new distyrylpyridine analogues bearing amide substructure as effective insecticidal agents

Research Authors
Aly Ahmed Abd-Ella
Research Abstract

In examining for unique insecticidal agents, two derivatives namely, 2-((3-cyano-4, 6-distyrylpyridin-2-yl) thio)-N-(4-nitrophenyl) acetamide (2) and 3-amino-N-(4-nitrophenyl)-4, 6-distyrylthieno [2, 3-b] pyridine-2-carboxamide (3) were synthesized from distyrylpyridine-2-thione (1). The new compounds were structurally clarified by spectral and elemental analysis data. The insecticidal activity of these compounds were carried out against cowpea aphid, Aphis craccivora Koch. It is demonstrated that the compounds 2 and 3 have noteworthy insecticidal activity against nymphs of cowpea aphid with LC50 values of 0.025-0.027 ppm and 0.005-0.006 ppm after 24 h and 48 h of treatment, respectively. Also, the compounds 2 and 3 have noteworthy insecticidal activity against adults of cowpea aphid with LC50 values of 0.112-0.129 ppm and 0.014-0.015 ppm after 24 h and 48 h of treatment, respectively, that were comparable to that of the control acetamiprid.

Research Date
Research Department
Research File
Research Journal
Current Chemistry Letters
Research Member
Research Publisher
www.GrowingScience.com
Research Rank
Q3
Research Vol
11
Research Website
http://m.growingscience.com/ccl/Vol11/ccl_2021_39.pdf
Research Year
2021
Research Pages
23-28