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Role of suberoylanilide hydroxamic acid and dapagliflozin on Cx43 gene expression in diabetic cardiomyopathy rat’s model

Research Authors
Mariam R.Abubeah 1, Heba M. Iraqy1, DaliaA. Elgamal2 & Enas Ahmed Hamed1
Research Date
Research Department
Research Journal
Scientific Reports
Research Year
2026

Therapeutic Effects of Lycopene and Aerobic Exercise in Skeletal Muscles Myopathy in Type 2 Diabetic Rat Model

Research Authors
Hassnaa M. A. Aleema,*, Rasha M. Alia,c, Marwa H. Bakrb,d, and Enas A. Hameda
Research Date
Research Department
Research Journal
Journal of Evolutionary Biochemistry and Physiology
Research Year
2026

Studying the effect of chronic toxicity of monosodium glutamate on interleukin-10 and interleukin-17 in albino Wistar rats

Research Abstract

Objective

This study aimed to assess the effect of chronic administration of Monosodium Glutamate (MSG) on blood cells, thymus, spleen, and inflammatory indicators through interleukin (IL)-17 and interleukin (IL)-10 gene expression levels in blood and in thymic and spleen tissues in male Wistar rats.

Methods

Rats were treated with MSG orally once daily for 90 days at two different doses with and without probiotic supplementation (Bacillus Subtilis and Bacillus Pumilus). Blood samples were collected for CBC, IL-10, and IL-17 gene expression in blood. The spleen and thymus were taken for histological and immunohistochemical studies.

Results

WBC results showed no significant difference among groups. A statistically significant higher mean IL-10 was observed among the low dose with probiotic (group 4) compared to other groups. There was a significantly higher mean of IL17 among low dose without probiotic (group 2). The mean level of IL-17 was high among group 4. Sections from thymus and spleen of MSG groups showed histological derangement. Immunohistochemical staining in tissues supported the observed gene expression levels in blood. Groups with higher cytokine gene expression generally showed stronger tissue staining, confirming consistency between transcription and protein levels and this strengthens interpretation of MSG-induced immune alterations.

Conclusion

High-dose MSG was associated with a decreased level of IL-10 with various degrees of tissue inflammation. Adding probiotics to low-dose MSG resulted in increased levels of IL-10 in blood. The low serum level of IL-17 in the high-dose MSG groups was associated with high degrees of inflammation with little improvement with probiotic.

Research Authors
Fatma Sayed Abd-Elsamea, Asmaa HM Soliman, Asmaa Abdo Abdelrahman, Omar Ali Mohamed Farghaly, Mostafa Sabry, Asmaa A Rayan
Research Date
Research Journal
Immunopharmacology and Immunotoxicology
Research Pages
148-163
Research Publisher
Taylor & Francis
Research Rank
International
Research Vol
48 (1)
Research Year
2026

Alloantibodies screening in cord blood for early detection of hemolytic disease of newborn

Research Abstract

Hemolytic disease of the newborn (HDN) is a disorder caused by antibodies from mother that pass through the placenta and attack red blood cells of fetus. Although other blood groups may potentially be implicated, Rh or ABO blood group incompatibility are the most common cause of this illness. Even though they are rarely linked to neonatal hyperbilirubinemia, minor blood group incompatibilities resulting from blood types other than Rh (D) are considered risk for significant jaundice and its complications in neonates if they are not properly identified and treated. In order to help clinicians reduce infant morbidity and improve overall patient care, the study's goal was to identify instances at elevated risk.

Research Authors
Nada O Abdelhameed, Eman Nasreldin, Shimaa Abdelaleem, Mariam E Abdallah
Research Date
Research Journal
The Egyptian Journal of Haematology
Research Pages
125-129
Research Vol
51
Research Website
https://journals.lww.com/egjh/fulltext/2026/01000/alloantibodies_screening_in_cord_blood_for_early.16.aspx
Research Year
2026

Diagnostic and Therapeutic Yield of Double-Balloon Enteroscopy in Small Bowel Diseases: A Prospective Cohort Study

Research Abstract


Diagnostic and Therapeutic Yield of Double-Balloon Endoscopy in Small Bowel Diseases: A Prospective Cohort Study

Research Date

Trichoscopy: a possible diagnostic role in autoimmune bullous diseases

Research Abstract

Autoimmune bullous diseases (AIBDs) are life-threatening diseases caused by immunologically mediated cell adhesion compromise in the skin and mucous membranes. Proposed diagnosis of AIBDs on a clinicopathological basis usually requires confirmation by other sophisticated and expensive laboratory facilities. This emphasizes the urgency of a simple, approachable and cost-effective method to clarify the diagnosis of AIBDs. This work aimed to outline the distinguishing trichoscopic characters of some immunobullous disorders [pemphigus vulgaris (PV), pemphigus foliaceus (PF) and bullous pemphigoid (BP)] in a group of Upper Egyptian patients and to examine any potential connections between these features and certain disease aspects. Sixty patients with AIBDs affecting the scalp were included. Twenty-nine patients were diagnosed as PV, seventeen patients were PF and fourteen were diagnosed as …

Research Authors
Nagwa Essa Abd Elazim, Ayman Mohamed Mahran, Tasbeeh Salah El-Deen, Aya Sayed, Alaa Ghazally
Research Date
Research Department
Research Journal
Archives of Dermatological Research
Research Pages
26
Research Vol
318
Research Website
https://link.springer.com/article/10.1007/s00403-025-04406-5
Research Year
2025
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