Stevioside and rebaudioside A revealed anticancer effects against diversity of cancers, such as colon, breast and
liver cancers. Rebaudioside A can trigger apoptosis in cancer cells via activation of caspase-dependent pathway.
In this study, sodium alginate/poly(N-vinylpyrrolidone) as nano-carriers loaded with natural products rebaudioside A (R) and/or stevioside (S) were assessed for anticancer activities. The nanogel of structure R improved
cytotoxicity against MCF-7, HepG2, HCT116 and A549 cancers by 60.29 %, 53.45 %, 72.86% and 62.13%,
correspondingly. Additionally, the nanogel of structure S improved cytotoxicity against MCF-7, HepG2, HCT116
and A549 cancers by 63.96%, 53.41%, 70.59% and 52.88%, respectively. Furthermore, the nanogel for
mixture of R/S improved cytotoxicity against MCF-7, HepG2, HCT116 and A549 cancers by 78.86%, 54.75%,
74.10 % and 56.53%, correspondingly. Also, cytotoxic activities of structures R, S and R/S and their nanogels
exhibited low toxicity on VERO cells with IC50 = 30.90–46.50 μM and high selectivity against cancer cells.
Moreover, R/S (nanogel), R (nanogel) and S (nanogel) demonstrated the uppermost binding affinities with DNA
at reduced IC50 values of 31.50, 32.60, and 33.90 μM, respectively. In addition, they inhibited Topo-II activity
with remarkably low IC50 values of 0.95, 1.00, and 1.10 μM, respectively.
Research Date
Research Department
Research Journal
International Journal of Biological Macromolecules
Research Publisher
Elsevier
Research Rank
Q1
Research Vol
316
Research Website
https://www.sciencedirect.com/science/article/pii/S0141813025053309
Research Year
2025
Research Member
Research Abstract