Do you have any questions? (088) 2080369 - 2345622 Pharmacy_QAAU@pharm.aun.edu.eg
God willing, The Medicinal Chemistry Department Council will hold its regular monthly meeting number (481) on Thursday, January 9, 2025, at 11:00 AM
In The Department Library
God willing, a meeting of the committee for community and environmental development will hold That will be on Thursday, January 9, 2025, at 10:00 AM
In the office of Vice Dean for Community Services and Environmental Development Affairs.
God willing, the laboratories and scientific equipment committee will hold its meeting That will be on Thursday, January 9, 2025, at 11:00 AM
in the office of Vice Dean for Community Services and Environmental Development Affairs.
God willing, the meeting of the Pharmaceutics Department Board of the Faculty of Pharmacy No. (534) this is on Monday, January 6, 2025, at 10:00 AM
in the department board on the third floor under the chairmanship of the Faculty to discuss the topics that we will inform you later.
God willing, The Pharmacognosy Department Council will hold its regular monthly meeting number (53) this is on Thursday, January 2, 2025, at 12:00 PM (noon)
In the department board meeting room.
Several studies have indicated the potential therapeutic outcomes of combining selective COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series of thiazolidin-4-one-based derivatives (7a–q) was designed by merging the pharmacophoric features of some COXs inhibitors and tubulin polymerization inhibitors. Compounds 7a–q were synthesized and evaluated for their cytotoxic activity against MCF7, HT29, and A2780 cancer cell lines (IC50 = 0.02–17.02 μM). The cytotoxicity of 7a–q was also assessed against normal MRC5 cells (IC50 = 0.47–13.46 μM). Compounds 7c, 7i, and 7j, the most active in the MTT assay, significantly reduced the number of HT29 colonies compared to the control. Compounds 7c, 7i, and 7j also induced significant decreases in the tumor volumes and masses in Ehrlich solid carcinoma-bearing mice compared to the control. The three compounds
