Indole-3-carboxylic acid hydrazide 3 was prepared and was treated with aromatic aldehydes in ethanol to give the corresponding hydrazone derivatives 4-7 in good yields. The indole carbohydrazide was incorporated into the 3-indolyloxadiazoles 8-11 and 18, 3-indolyltriazoles 13-17 and 35, 3-indolylpyrazole derivatives 19-23 and carbamate derivatives 26-27. Furthermore, interaction of the carboazide 24 with hydrazine hydrate in refluxing toluene afforded the corresponding semicarbazide derivative 30. The thiadiazine derivative 34 was also prepared. Some of these compounds were screened in vitro for their antibacterial and antifungal activity