Pospectiv studies suggest that tea may protect against oxidative stress that induced tissue damage. A potential mechanism fr such effect y polyphenolc antioxidant tannic acid derived from tea was evaluated in tis study. Treatment of rats with ALCL3 for 80 days caused moderate toxicity on liver, kidney and splen as evidenced by increased LPO& No and a reduction of SOD,CAT, GST, GSH nd vitamin E.As well as histopathological changes.However improvement was noticed in the rats treated with tannic acid.