The global feeding on Western diet, which is enriched in fat and fructose, has been proposed to be a cause of
metabolic disorder, including hepatic steatosis which is associated with oxidative stress. In the present study,
we investigated the influence of co-treatment with phytochemical compounds, quercetin (Q), o-coumaric
(CA) and berberine (BB) on the hepatic lipid profile and oxidative stress markers of rats fed a HFS diet. Rats
fed HFS diet showed hypertriglycemia, hypercholesterolemia, and alteration of oxidative markers in hepatic
tissues and serum and histological changes in liver tissues. Supplementing a HFS diet with CA and BB
ameliorates hypertriglycemia, hypercholesterolemia and oxidative stress biomarkers. However, Q improved
the biochemical changes in lipid profile and oxidative stress, but failed to improve the histological changes in
liver tissue. In conclusion, the present results evidences indicate that CA and BB could be considered as
promising complementary treatments against hepatic steatosis development associated with HFS.