Schistosomasis is one of the most tropical neglected diseases (NTDs), which have very complex antigenically different life stages. So that studying the effect of each antigen on cellular immune response is required. Three schistosomal antigens were used CAP,
SEA and SWAP separately in vivo. Blood parameters and lymphocytes blastogenesis were evaluated. The most changes were reported in
WBCs and differential cells with maximum immune response after 33 dpv in CAP and 47 dpv in SEA and SWAP. These changes reflected the defense and cellular immune response for each antigen.