Self-assemblyofbenzene-1,4-dicarboxylatewithCu(II)usingultrasonicassistedapproacheswith2-aminothia zole assecondaryligandproduceacoordinationpolymeroftheformula{[Cu(BDC)(AZ)(H2O)].H2O}n.The structurewasinvestigatedusingelementalanalysis, IR spectroscopy,X-raydiffraction(XRD)andTransmission electron microscopy (TEM).Acrystalline coordinationpolymerwasobtainedvia theultrasonic irradiation. Coppercompoundsexhibitedpromisinginhibitoryactionagainstsixhumanpathogenicbacteria(Bacillussubtilis, Bacillus cereus, Escherichia coli, Klebsiellapneumoniae,Micrococcus luteus, andSerratiamarcescens). The most effective antibacterial treatments were after sonicationfor70minespeciallyat100µg/mlgives total counts 32.96×107±0.56,32.68×107±0.84,28.32×107±1.2,9.16×107±0.52,20.92×107±0.2,and30.36 ×107±0.28,forB.subtilis,B.cereus,E.coli,K.pneumoniae,M. luteus,andS.marcescenscomparingwithcontrol samples82.84×107±5.96,94.04×107±3,65.24×107±1.08,32.92×107±0.6,36.92×107±0.2,and 59.52×107±0.4,respectively.