Assessment of hemodynamics, blood gases, and lung histopathology of healthy Pig model on two different mechanical ventilators
Research Abstract
In response to COVID-19 global crisis and arising from social responsibility, efforts have been
exerted to promptly research, develop and manufacture ICU ventilators locally to meet the spike in demand.
This study aimed at: Evaluating the safety and performance of a newly developed mechanical ventilator;
EZVent compared to a commercial ventilator regarding hemodynamics, arterial blood gases (ABG), lung in-
flammatory markers, and histopathology in a healthy pig model using three different ventilation modes.
Methods: Eight adult male pigs were anesthetized and randomly assigned into two equal groups: Commercial
vent and EZVent group, the animals of which were ventilated using a standard commercial ventilator and
EZVent, respectively. On every animal, three ventilation modes were tested, each mode for 30 min: CMV-VC,
CMV-PC, and CPAP-PS modes. Vital signs, ECG, Lung Mechanics (LM), and ABG were measured before
ventilation and after 30 min of ventilation of each mode. After animals’ euthanasia, histological examinations
of lung samples including morphometric assessment of alveolar edema, alveolar wall thickening, and the mean
number of inflammatory cellular infiltrate/cm2 of lung tissue were analyzed. TNF-α and Il-6 expression and
localization in lung tissue were assessed by western blot and immunohistochemistry. Results: The vital signs,
Research Date
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Assessment of hemodynamic.pdf
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