Background:The object of this work was to evaluate of the hepatic effects of the herbicides glyphosate-Roundup®
by different doses in both sexes of albino rats.
Methods:Forty animals divided into four groups with ten animals for each (both sexes) were treated orally with
vehicle (controls) and 25, 50, and 100 mg/kg bwt of glyphosate-Roundup® (treated groups) for 15 days daily.
Results:The most conspicuous changes occurred on the liver treated groups due to glyphosate toxicity were the
increase of enzymes activities of ALT and AST, cellular infiltration, many signs of nucleus degeneration, focal
necrosis, rarified cytoplasm, disorganization of cellular organelles, and deposition of lipid droplets. The increase in
the amount of collagenous fibers and the number of the mast cell were also observed.
Conclusion:Our results indicated that the administration of glyphosate-Roundup® in different doses may cause
adverse effects on the histopathological, ultrastructure, and biochemical alternations on the liver of the albino rats.
Keywords:Glyphosate-Roundup®, ALT and AST, Liver, Histopathology, Ultrastructure
ملخص البحث
تاريخ البحث
قسم البحث
مجلة البحث
The Journal of Basic and Applied Zoology
المشارك في البحث
الناشر
the Springer Nature
عدد البحث
79
موقع البحث
https://doi.org/10.1186/s41936-018-0060-4
سنة البحث
2018
صفحات البحث
48