Purpose: Retinal and inner ear ribbon synapses are specialized sensory synapses characterized by synaptic ribbons,
electron-dense and protein-rich structures that enable rapid and sustained neurotransmitter release. This review aims to
examine the molecular architecture of ribbon synapses with a particular focus on the potential involvement of Tiam1, a
guanine nucleotide exchange factor implicated in neuronal development and synaptic plasticity.
Methods: A comprehensive review of the available literature was conducted to summarize current knowledge on the
structural organization and molecular components of ribbon synapses. Particular attention was given to studies investigating Tiam1 expression, function, and its possible role in cytoskeletal remodeling and synaptic regulation.
Results: Evidence supports the central role of RIBEYE as the primary structural component of ribbon synapses; however, the regulatory mechanisms governing ribbon formation and function remain incompletely understood. Recent studies suggest a potential contribution of Tiam1 in modulating synaptic organization and function through Rac1 activation
and cytoskeletal regulation, although direct experimental evidence in ribbon synapses is still limited.
Conclusions: Ribbon synapses are critical for sustained neurotransmission in sensory systems, yet their molecular
regulation remains incompletely defined. Tiam1 emerges as a promising candidate molecule that may influence ribbon
synapse function. Future experimental studies are needed to clarify its localization, molecular interactions, and contribution to synaptic organization and plasticity. 
 

The neural crest (NC) is a transient, multipotent cell population that contributes extensively to vertebrate embryogenesis, generating craniofacial structures, peripheral nerves, melanocytes, and cardiovascular elements. While
classically studied in the context of development, increasing evidence demonstrates that NC-derived cells persist into adulthood, where they support tissue
homeostasis, plasticity, and repair. This review synthesizes current insights
into the lifelong impact of the NC, with emphasis on aging, degeneration, and
regeneration. We first outline the developmental origins and lineage diversification of NC cells, highlighting mechanisms that establish long-lived progenitor pools. We then examine how age-related changes in NC-derived tissues,
including craniofacial bone remodeling, pigmentary alterations, autonomic
decline, and peripheral neuropathies, reflect broader principles of cellular
senescence and disrupted signaling. The involvement of NC derivatives in ageassociated pathologies, such as neurodegeneration, cardiac anomalies, and craniofacial degeneration, is also addressed. Finally, we highlight progress in
regenerative medicine that leverages NC-derived stem and progenitor cells,
together with molecular pathways that may rejuvenate their function in aging
tissues. By integrating developmental, pathological, and regenerative perspectives, this review positions the NC as a central contributor to organismal aging
and underscores its translational relevance. We also outline unresolved questions and future research directions at the interface of NC biology, aging, and
regenerative medicine. 
 

Sedation is increasingly preferred for patients undergoing colonoscopy to improve tolerance and procedural success. This study aimed to compare the sedative and analgesic profiles, as well as hemodynamic responses, of dexmedetomidine and nalbuphine during elective colonoscopies.

Background: Breast cancer (BC) is a leading cause of cancer-related mortality in women worldwide. Early detection significantly improves outcomes, yet current diagnostic methods, such as mammography and biopsy, have limitations, particularly in detecting early-stage disease. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for cancer detection. Objective: This study aims to evaluate the expression of serum miR-373 and miR-660-5p in breast cancer patients and their association with clinicopathological parameters. Methodology: This is a casecontrol study was conducted on 25 breast cancer patients and 25 age-matched healthy controls. Serum miRNA-373 and miRNA-660-5p levels were measured using quantitative real-time polymerase chain reaction (qPCR). Clinical and pathological data, including tumor stage, histological type, and molecular markers, were collected. Statistical analysis was performed to assess the differences in miRNA expression and their correlations with clinicopathological parameters. Results: Breast cancer patients exhibited significantly higher serum levels of miR-373 and miR-660-5p compared to controls (p < 0.001 and p = 0.030, respectively). MiR-373 expression was significantly associated with advanced tumor stages and nodal involvement (p = 0.008). However, miR-660-5p showed no significant correlation with clinicopathological features. The combined use of miR-373 and miR-660-5p improved diagnostic accuracy, with an area under the curve (AUC) of 0.859. Conclusion: Serum miR-373 and miR-660-5p are potential non-invasive biomarkers for breast cancer detection. MiR-373, in particular, shows promise in identifying advanced disease stages. Combining these miRNAs enhances diagnostic accuracy, offering a potential tool for early breast cancer diagnosis.