Bisphenol A (BPA) is a chemical material that using in polycarbonate
plastic that is widely used in daily life items. Several studies showed the
adverse effect on the health of erythrocytes in both human and animals, while
gallic acid (GA) is a known antioxidant capable of counteracting free radicals.
In this study included 4 groups 10 rats each. The first was the control. The
second received BPA in drinking water was given ad libitum at dose
40mg/kg.b.w. The third and fourth groups was given BPA by the same dose
and by the same route in addition to receive GA in the diet at doses of 50 and
200 mg/kg.b.w, respectively. In erythrocytic hemolysate, the antioxidants:
glutathione (GSH), activities of both superoxide dismutase (SOD) and catalase
(CAT) were estimated. Also, lipid peroxidation (LPO) and carbonyl protein
(CrPr) were determined. The results showed that BPA significantly increased
LPO and CrPr and decreased the activities of CAT, SOD and the GSH
content. However, the treatments of the BPA-intoxicated rats with GA
reversed the erythrocytic oxidative damage and curtailed the decrease in
antioxidants. In conclusion, the GA with both doses could attenuate the
oxidative damage in erythrocytes of rats-treated with BPA.