Pyrazoles are five membered heterocycles constitute a higly significant class of compounds in organic synthesis. Nowadays, pyrazoles and condensed pyrazoles have attracted substantial attention of the scientists owing to their excellent pharmacological and agrochemical properties. Pyrazole derivatives exhibit a wide range of pharmacological effects such as: anticancer, antioxidant, anti-inflammatory, antipyretic, analgesic, antimicrobial, antidepressant, antiviral, antihypertensive, anti-glaucoma, anti-tubercular, sodium channel blocker, anxiolytic, neuroprotective and anti-diabetic activities. This review casts light on recent methodologies for the synthesis and reactions of thienopyrazole moiety. This follow-up may encourage scientists to create new routes towards the thienopyrazole nucleus with important biological activity.