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Effect of diabetes control or growth hormone and somatomedin-C levels in young subjects with insulin-dependent diabetes mellitus

Research Authors
Al-Sawi N.M
Sobh M.A
Ghazally M.H
Hossam El-Din M Omar
Research Abstract

serum levels of GH, Somatomedin-C as well as linear body growth were determined in 28 young diabetic subjects (14 children and 14 preadolescents) and in 20 normal age-matched control. All children and 50% of the preadolescent patients were poorly controlled. The mean hight in both groups was insignificantly lower than that in controls. Serum GH was higher in both groups while SM-C was insignificantly lower in children and insignificantly higher in preadolescents than that in the controls. An inverse correlation between GPP and SM-C in the poorly controlled preadolescent diabetics. These finding may suggest that the decreased linear growth results in poorly controlled diabetics from decreased serum SM-C. Meanwhile, the elevated GH levels may imply a state of GH resistance and may help to explain the inadequate diabetes control among this group patients.

Research Department
Research Journal
Arab.J.Lab.Med.
Research Member
Research Publisher
Cairo University Press
Research Rank
2
Research Vol
20 (1)
Research Year
1994
Research Pages
8997