The endocrine disrupting substances represent major challenge to aquaculture and the most
widespread one is 4-nonylphenol (4-NP). Pyrazole possess an interesting broad spectrum of
pharmacological actions. Therefore, this study was designed to investigate the therapeutic potential
of five novel thieno [2,3-c] pyrazole compounds in African catfish (Clarias gariepinus) on the
hematotoxic and electrolyte disruptor influences of 4-NP. The hemato-electrolyte disturbance
induced by 4-NP was well proved by many examined endpoints. On the other hand, thienopyrazole
compounds exhibited the ability to modulate the previous toxicological impact by different levels
based on the modification in structures and properties. This study provided insight into the endless
therapeutic treasures of newly synthesized complexes, and a driving force for its application on the
other clinically relevant problems in fish.