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A Facile Method for the Synthesis of Hydrazine-4-oxothiazolidine and
Imino-5-oxothiadiazine Derivatives from 1,4-Disubstituted
Thiosemicarbazides

Research Authors
Alaa A. Hassan, Ashraf A. Aly, Tarek I. M. Bedair, Alan B. Brownb and Talaat I. El-Emaryc
Research Abstract

Disubstituted thiosemicarbazides reacted with dimethyl acetylenedicarboxylate with formation of
(2-hydrazono-4-oxothiazolidin-5-ylidene)acetates and, in one case, a (2-imino-1,3,4-thiadiazin-5-on-6-
ylidene)acetate. Several mechanistic options involving nucleophilic interaction are presented. The structures
of all newly synthesized compounds were identified by 1H NMR, 13C NMR, COSY, HMQC and HMBC
spectral data.

Research Department
Research Journal
Heterocyclic Chemistry
Research Member
Research Rank
1
Research Vol
51
Research Year
2013