Abstract
Our present study provides expedient methods for the synthesis of novel substituted indanes, pyrido[3,2,1-
jk]carbazoles and pyrido[3,2,1-kl]phenothiazines utilizing intramolecular Friedel-Crafts cyclialkylations of
synthesized heteroaryl alcohols. This methodology is realized by a three-step protocol involving first
esterification of starting carboxylic acids to the corresponding esters, addition of Grignard reagents to give
carbinol precursors and followed by Friedel-Crafts cyclizations of alcohols mediated by AlCl3/CH3NO2, PPA or
P2O5-catalysts to furnish the desired polycycles in good to excellent yields of 65-85%. The designed protocol
offers easy access to the pharmaceutically promising templates in good yields. The molecular structural
elucidations of all newly obtained compounds have been proved by spectral and elemental analysis.