5-Cyano-4-oxo-6-phenyl-2-thioxo-l,2,3.4-tetrahydro pyrimidine1 (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (118-g); and with chloroacetic acid ethyl chloroacetate to give compounds 111 and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g). The parent thiazolo[3,2-a]pyrimidine (VI) was prepared from compound 111 by refluxing with acetic anhydride. Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo(4.3-a] pyrimidine derivatives. The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure
Research Abstract
Research Department
Research Journal
Phosphorus, Sulfer and silicon
Research Member
Research Rank
2
Research Vol
Vol. 45, No 1-2
Research Year
1989
Research Pages
pp. 81 - 93