First synthesis and biological evaluation of indeno[2,1-e]pyrazolo [3,4-b]pyrazin-5-one and related derivatives

كلية العلوم

Assiut University

First synthesis and biological evaluation of indeno[2,1-e]pyrazolo
[3,4-b]pyrazin-5-one and related derivatives

Research Authors
Talaat El-Emary, Hussein El-Kashef
Research Abstract

The synthesis of indeno[2,1-e]pyrazolo[3,4-b]pyrazin-5-onewas achieved by intramolecular FriedeleCrafts
reaction of the acid chloride 3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b] pyrazine-5-carboxylic acid chloride
(4) using AlCl3 in boiling CS2. Compound 4 proved to be a versatile compound for the synthesis of several
Indenopyrazolopyrazinone derivatives. The antibacterial and antifungal activities of selected derivatives
were evaluated.

Research Department
Department of chemistry
Research Journal
European Journal of Medicinal Chemistry
Research Member
Hussein Mohamed salama El-kashef
Research Rank
1
Research Vol
Vol. 62
Research Year
2013
Research Pages
PP. 478-485