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Synthesis, reactions, and spectral characterization of some new biologically active compounds derived from thieno[2,3-c]pyrazole-5-carboxamide

Research Authors
Ahmed F. Saber, Remon M. Zaki, Adel M. Kamal El-Dean, Shaban M. Radwan
Research Abstract

The starting compound 4-amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-
5-carboxamide (1), that has been previously synthesized according to the literature
procedure, underwent a reaction with the anhydride of phthalic acid
either in AcOH or DMF to give isoindolinylpyrazole-5-carboxamide 3 and
pyrazolothienopyrimidoisoindoledione 4, respectively. Also, it was subjected to
react with diethylmalonate followed by hydrazinolysis by hydrazine hydrate to
yield the pyrazolothienopyrimidinyl acetohydrazide 5. The carbohydrazide
derivative 5 was used as a key intermediate for the preparation of other new
heterocyclic systems containing pyrazolylacetyl pyrazolothienopyrimidines
and pyrazolothieno-pyrimidotriazepine compounds 6–11. The structures of
these new heterocycles have been characterized by using analytical and spectroscopic
analyses (IR, 1H-NMR, 13C-NMR and MS). Some derivatives of the
synthesized compounds exhibited remarkable antibacterial and antifungal
activities against many bacterial and fungal strains.

Research Department
Research Journal
Journal of Heterocyclic Chemistry
Research Publisher
Wiley
Research Rank
1
Research Vol
Vol. 57
Research Website
https://doi.org/10.1002/jhet.3769
Research Year
2020
Research Pages
pp. 238–247