Mixed convection has been one of the most interesting subjects of study in the area of heat transfer for many years. The entropy generation due to MHD mixed convection heat transfer in L-shaped enclosure being filled with Cu-water nanofluid and having an internal heating generation is explored in this investigation by the finite volume technique. Lid-motion is presented by both right and top parts of walls to induce forced convection and the cavity is under an inclined uniform magnetic field along the positive horizontal direction. The statistics concentrated specifically on the impacts of several key parameters like as the aspect ratio of the enclosure, Hartmann number, nanoparticle volume fraction, and heat source length/location on the heat transfer inside the L-shaped enclosure. Outcomes have been manifested in terms of isotherm lines, streamlines, local and average Nusselt numbers. The obtained results show that addition of nanoparticles into pure fluid leads to increase of heat transfer. The maximum value of local Nusselt pertaining to the heat source occurs when L = 0.1. Impacts of heat source size and location, internal heat generation absorption, angle of magnetic field on heat transfer and entropy generation are completely analyzed and discussed. The best configuration and values of important parameters are also presented using thermal performance criteria.