Acyclovir (ACV) and Omeprazole (OMP) are two expired drugs examined as an inhibitors for the dissolution of Sabic iron in 1.0 M HCl using weight loss, electrochemical impedance and two types of polarization; galvanostatic and potentiodynamic measurements . Increase the concentration of expired ACV and OMP increases the efficacy of inhibition that also decreases with temperature. These drugs acts as mixed inhibitors that was detected by galvanostatic polarization studies. The inhibition activity of ACV and OMP owing to its horizontal adsorption of them on the Sabic iron surface because of the presence of several active centers. The adsorption follows Langmuir isotherm. The impedance data demonstrated one capacitive loop suggesting that the charge transfer control the corrosion reaction. The expired ACV and OMP performed as an efficient pitting corrosion inhibitor by moving the pitting potential to more noble values.