A novel In2O3 nanoparticles modified glassy carbon paste electrode (In2O3NPs/GCPE) was prepared and
applied for selective and sensitive electrochemical determination of luteolin (LU). Scanning electron
microscopy (SEM) was used for the characterization of In2O3NP modifier and its morphology on the
surface of GCPE. The modified electrode showed excellent electrocatalytic activities with respect to LU
oxidation, with good reproducibility. The electrochemical parameters such as surface concentration (),
electron transfer coefficient (˛) and the standard rate constant (ks) of LU at the modified electrode were
calculated. Under the optimized experimental conditions, the proposed sensor exhibited a rapid response
to LU in a linear range from 9.98 × 10−9 M to 8.84 × 10−8 M LU and a low detection limit was found to
be 1.99 × 10−10 M LU. The analytical performance of this sensor was evaluated for the detection of LU in
spiked human biological fluids and in thyme as a real sample with good accuracy and precision.