Morelia City stands in central México, within the Trans-Mexican Volcanic Belt and the Michoacán-Guanajuato volcanic field. With a population of about 850,000, it is the largest and most populated city in the state of Michoacán. In 1991, UNESCO designated its historic center as a World Heritage Site, attracting millions of tourists yearly. However, the city is vulnerable to regional intraplate and inter-plate earthquakes and the municipality’s outdated building regulations. Recently, the strong shaking experienced in the metropolitan area due to the November 19th, 2022 (Mw7.7) subduction earthquake on November 19th, 2022 (Mw 7.7), emphasizes the need to understand the site's effects and to update the municipality’s building regulations. This study presents a comprehensive seismic microzonation of Morelia, using the ambient noise horizontal-to-vertical spectral ratio (HV) technique as an initial step toward mitigating seismic risk. Because of several peaks in the HV, we presented the HV amplification at several frequencies and not only at the dominant frequency, as is usually the case. We identified amplification levels of up to 6.0. We also inverted the HVs, considering the thicknesses identified by geological data, to create a velocity model of the subsurface extending to a depth of 400 m. The results indicate the existence of a local half-graben where the sediment thickness ranges from 50 to 110 m and define the regions with the most significant amplification. Furthermore, we reported the existence of long-period ground vibrations that could affect high-rise buildings, long-span bridges, and historical buildings. Since HV ambient noise amplification maps do not always effectively predict earthquake responses, we also compared these maps with acceleration maps from two recorded earthquakes at similar frequencies. One of these earthquakes was a subduction event, while the other originated from a local source. They exhibited low and high central frequency sources, respectively, as recorded by the accelerograph network of the Universidad Michoacana. The excellent correspondence between all the output results indicates the reliability of the used approach.