Self-assembly of benzene-1,4-dicarboxylate with Cu (II) using ultrasonic assisted approaches with 2-aminothiazole as secondary ligand produce a coordination polymer of the formula {[Cu (BDC)(AZ) (H₂O)]. H₂O}_n. The structure was investigated using elemental analysis, IR spectroscopy, X-ray diffraction (XRD) and Transmission electron microscopy (TEM). A crystalline coordination polymer was obtained via the ultrasonic irradiation. Copper compounds exhibited promising inhibitory action against six human pathogenic bacteria (Bacillus subtilis, Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Micrococcus luteus, and Serratia marcescens). The most effective antibacterial treatments were after sonication for 70 min especially at 100 µg/ml gives total counts 32.96 × 10⁷ ± 0.56, 32.68 × 10⁷ ± 0.84, 28.32 × 10⁷ ± 1.2, 9.16 × 10⁷ ± 0.52, 20.92 × 10⁷ ± 0.2, and 30.36 × 10⁷ ± 0.28, for B. subtilis, B. cereus, E. coli, K. pneumoniae, M. luteus, and S. marcescens comparing with control samples 82.84 × 10⁷ ± 5.96, 94.04 × 10⁷ ± 3, 65.24 × 10⁷ ± 1.08, 32.92 × 10⁷ ± 0.6, 36.92 × 10⁷ ± 0.2, and 59.52 × 10⁷ ± 0.4, respectively.