1-Hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (3) was subjected to react with
bifunctional compounds namely: acetylacetone, ethyl cyanoacetate, ethyl benzoylactate, diethylmalonate
and ethyl acetoacetate to produce pyrazololthienotetrahydroisoquinoline derivatives 6e11. Also, heating
of compound (3) with formic acid afforded triazolothienotetrahydroisoquinoline compound 5 which
reacted with a-halogenated compounds to afford compounds 13aee. Compound 13c when heated with
triethylorthoformate afforded triazolo derivative 14. Also, compound 6 was used for synthesizing
compounds 18e20. Representative compounds of the synthesized triazolo and pyrazolothienotetrahydroisoquinoline
products were tested and evaluated as antimicrobial agents.