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Synthesis and Characterizations of Some New Selenolo[2,3-b]quinoxaline Derivatives

Research Authors
Fatma K. Abdelwadoud, Gehad S. Gomaa, Ahmed A. Geies
Research Abstract

In this paper, we present the synthesis of new selenoloquinoxaline derivatives starting from 2-Chloroquinoxaline-3-carbonitrile 1. The compound 1 was subjected to a reaction with Selenium metal in the presence of NaBH4 as a reducing agent in ethanol, under a nitrogen atmosphere. This reaction resulted in the formation of the sodium salt of 3-cyanoquinoxaline-2-selenolate, which was subsequently reacted with α-halogenated carbonyl compounds in situ. This reaction produced a serious of newly synthesized 3-aminoselenolo[2,3-b]quinoxaline-2-substituents. Ethyl 3-aminoselenolo[2,3-b]quinoxaline-2-carboxylate 3a was hydrolyzed by sodium hydroxide to give the corresponding sodium salt 9. This salt was then refluxed with acetic anhydride to produce oxazinone compound 10. The reaction of compound 10 with ammonium acetate afforded pyrimidoselenolo[2,3-b]qinoxaline derivative 11. Compound 11 was then Chlorinated using phosphorous oxychloride to give the corresponding chlorocompound.

Research Date
Research Department
Research Journal
Journal of Heterocyclic Chemistry
Research Publisher
John Wiley & Sons, Inc.
Research Vol
61
Research Website
https://onlinelibrary.wiley.com/doi/abs/10.1002/jhet.4754
Research Year
2024