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Synthesis, Anti-Diabetic and Renoprotective Activity of Some New Benzazole, Thiazolidin-4-one and Azetidin-2-one Derivatives

Research Authors
Ahmed Abdou O Abeed, Mohamed Salah K Youssef, Rehab Hegazy
Research Abstract

A new series of benzazole, thiazolidinone and azetidin-2-one derivatives incorporating to pyrazole moiety were synthesized by condensation of 1,3-diphenyl-1H-pyrazol-4-carboxaldehyde with different nucleophiles. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Some of these compounds were evaluated for their anti-hyperglycemic and renoprotective activities. Three compounds showed remarkable anti-diabetic potency, whereas other five compounds showed significant renoprotective activity.

Research Department
Research Journal
Journal of the Brazilian Chemical Society
Research Member
Research Publisher
NULL
Research Rank
1
Research Vol
Vol.28, No.11
Research Website
http://dx.doi.org/10.21577/0103-5053.20170050
Research Year
2017
Research Pages
PP.2054-2063