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Synthesis of Tricylic Compounds with Thiopyridone Rings

Research Authors
Kh.M. Hassan, G.M. El-Naggar, A.M. El-Khawaga and A.M. Kamal El-Dean
Research Abstract

Reaction of 3,4-trimethylene-6-amino-5-ethoxycarbonylthiopyrane-2-thione (1) with hydrazine hydrate gave the corresponding o-diaminocyclopentapyridine-2-thione (2). Ring closure of 2 with some reagents, namely, formic acid, aromatic aldehydes, carbon disulphide. phenacyl bromide, ethyl chloroformate, ethyl chloroacetate, nitrosylsulfuric acid, and pyruvic acid gave tricyclic compounds (2-14) by direct or indirect pathways, respectively.

Research Department
Research Journal
2nd Ibn Sina Symposium 8-11 November, 1988, St. Catherine Sinai, Egypt & Phosphorus, Sulfur, and Silicon and the Related Elements,
Research Rank
1
Research Vol
Vol. 45, No. 3,4
Research Year
1989
Research Pages
pp. 261 - 267