A simple and efficient one-pot three component synthesis of spiro{pyrido[2,1-b]benzothiazole-3,3'-indoline} and/or spiro{thiazolo[3,2-a]pyridine-7,3'-indoline} derivatives were carried out by the reaction of 2-mercaptoaniline and/or mercaptoacetic acid, malononitrile, and a series of 2-oxoindoline-3-ylidines in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling.