The Middle East is suffering from water scarcity in the arid/semiarid settings. The recent advance of technologies in the geophysical fields made groundwater monitoring possible from space. Time-variable gravity data and climatic model are utilized to monitor mass variations caused by groundwater changes over the Sinai Peninsula during the period 04/2002-07/2016. Results are: (1) Sinai Peninsula is receiving low average annual precipitation (AAP) rate, varying from 22.3 mm/yr to 68.5 mm/yr; (2) The average annual Terrestrial Water Storage variations (ΔTWS) were estimated at -3.92 ± 0.23 mm/yr; (3) The average yearly non-groundwater components were estimated at -1.35 ± 0.032 mm/yr; (4) The average annual groundwater
storage variations (ΔGWS) were estimated at -2.57 ± 0.22 mm/yr. The depletion in the mass variations over Sinai seems to be caused by the natural discharge, low rainfall rates, and the surface runoff from the land
toward the water bodies. The integrated approach is informative and a replicable study for the areas of poor information.